CalciMedica is trading at $2.25, up 5.14% in pre-market following significant post-split volatility. * Stonepine Capital Management expanded its stake in CalciMedica on August 19, 2026, a move that is now being highlighted as a potential driver for the stock's recent surge. * The company's 1-for-5 reverse stock split became effective at 5:00 p.m. ET on August 28, 2026, with split-adjusted trading beginning August 31, 2026. * Shares gained 360.81% on August 31, indicating continued high volatility.